MOTS-c 10mg Snap Pen

MOTS-c is a 16–amino-acid peptide encoded in the mitochondrial 12S rRNA gene (MTRNR1). In research models it activates AMPK and related stress-response pathways, improves glucose and lipid handling, and helps cells adapt to metabolic stress. Interest has grown as studies show MOTS-c rises with exercise, supports metabolic flexibility, and may counter aspects of age-related metabolic decline.

What it does

• Turns on “cellular energy” switches – Promotes AMPK-driven pathways that help burn fuel efficiently and clear metabolic by-products.
• Improves insulin response – Aids glucose uptake and supports healthier blood-sugar control in preclinical and early human studies.
• Boosts exercise adaptation – Linked with better exercise tolerance and recovery signaling; levels increase with training.
• Supports healthy body composition – In animal models, helps limit fat gain and encourages better fuel use (fat oxidation).

Research is ongoing. Findings come from cell, animal, and early human studies; MOTS-c is investigational outside approved indications.

How it works (at a glance)

• AMPK pathway – MOTS-c raises AMP:ATP-like signaling to trigger AMPK, promoting glucose uptake, fatty-acid oxidation, and mitochondrial biogenesis signals.
• Folate-metabolism interface – Interacts with one-carbon/folate pathways that influence stress responses and cellular redox balance.
• Exercise-inducible signal – Circulating MOTS-c increases with acute/chronic exercise and may act as a nucleus-directed “mitokine” to tune gene expression for metabolic resilience.