TB-500 (Thymosin Beta‑4): Accelerated Healing & Inflammation Control
Rapid Tissue Recovery, Enhanced Flexibility, and Cellular Regeneration
TB 500 is a synthetic fragment of thymosin beta‑4, a naturally occurring peptide vital for cell movement, tissue repair, and new blood vessel formation. Engineered for improved stability and delivery, TB 500 research shows promising signs of targeted healing benefits across muscle, tendon, ligament, skin, and even internal organs. It may support faster recovery from injury, reduces chronic inflammation, and helps restore functional mobility.
Designed for research of active individuals and those in recovery, TB 500 works systemically traveling through the bloodstream to reach damaged areas. This makes it ideal for those dealing with sports injuries, post-surgical healing, chronic joint pain, or tissue damage. Its powerful angiogenic and anti-fibrotic effects also show promise in heart, eye, and neurological healing.
TB 500 purportedly targets several key processes to support systemic healing:
- Actin Regulation & Cell Migration: Binds G‑actin to regulate cytoskeletal dynamics, facilitating cell movement into injured tissues.
- Angiogenesis: Stimulates endothelial cell migration and capillary formation to improve circulation and nutrient flow.
- Anti-Inflammatory Pathways: Modulates immune response, reduces neutrophil activity, cytokine release, and apoptosis, promoting a healing environment.
- Tissue Remodeling & Fibrosis Reduction: Encourages collagen deposition while preventing excessive scarring for better elastic recovery.
Key Potential Benefits
- Accelerated Wound Healing – In rat models, TB 4/TB 500 increased wound re-epithelialization by up to 61% at day 7, with boosted collagen deposition and angiogenesis.
- Enhanced Cell Migration & Tissue Repair – Promotes actin modulation for efficient cellular repair, essential for healing muscle, tendon, ligament, and skin damage.
- Improved Flexibility & Reduced Fibrosis – Encourages tissue remodeling and elasticity by regulating F-actin and limiting scar tissue formation.
- Angiogenesis & Blood Flow Support – Stimulates new blood vessel growth, enhancing nutrient delivery to damaged tissues and supporting cardiac regeneration.
- Anti-Inflammatory Action – Reduces pro-inflammatory cytokines, promotes anti-inflammatory responses, and supports recovery from chronic inflammation.
- Muscle Regeneration & Performance Maintenance – Accelerates muscle repair, aids endurance, and supports maintenance of muscle quality after injury.
- Organ & Vascular Regeneration – Preclinical data supports benefits in heart, eye, and nerve recovery via enhanced endothelial and cardiac cell survival.
Research Sources
- Thymosin beta‑4 accelerates wound healing
- The regenerative peptide thymosin β4 accelerates the rate of dermal healing
- TB‑4 improves endothelial dysfunction and angiogenesis in diabetic hiPSC‑ECs
- Thymosin beta‑4 enhances the healing of medial collateral ligament
- Thymosin β4: a multi-functional regenerative peptide
- Beneficial effects of thymosin β4 on spinal cord injury
- Thymosin beta‑4 and corneal wound healing
Technical Information
CAS Number: | 885340-08-9 |
PubChem CID: | 62707662 |
Formula: | C38H68N10O14 |
Synonyms: | TB500, 885340-08-9, UNII-QHK6Z47GTG, TB-500, QHK6Z47GTG |