SS‑31 (Elamipretide): Mitochondrial Protector & Energy Booster
Restore Cellular Power, Reduce Oxidative Damage, and Support Organ Health
SS‑31, also known as Elamipretide, is a synthetic tetrapeptide that selectively targets mitochondria, the powerhouses of our cells. Research studies indicate due to aging, disease, or stress, mitochondrial membranes can deteriorate, causing less energy production and increased oxidative damage. SS‑31 binds to cardiolipin, a key lipid in the inner mitochondrial membrane, stabilizing its structure and restoring efficient energy generation.
SS‑31 accumulates within mitochondria’s inner membrane and performs several protective actions:
- Cardiolipin Stabilization – Binds cardiolipin to maintain mitochondrial architecture and optimize electron transport function.
- Oxidative Stress Reduction – Lowers mitochondrial ROS, increases SOD activity, and limits oxidative damage.
- Improved ATP Generation – Restores redox balance and supports efficient energy production without increasing mitochondrial mass.
- Mitochondrial Structure Repair – Long-term SS‑31 reversed structural damage and mitophagy defects in Barth syndrome mouse models.
- Organ-Level Benefits – Demonstrated cardioprotective effects in human and animal studies; showed protection against kidney and brain inflammatory damage.
By protecting mitochondria from oxidative stress and improving electron transport chain function, SS‑31 shows promising study results in supporting cellular vitality in high-energy organs (heart, brain, muscle, kidney). Research shows benefits in aging-related dysfunctions, muscle endurance, cognitive protection, and mitochondrial diseases, often potentially reversing cellular decline at its root.
Key Potential Benefits
- Enhanced Cellular Energy – Improves mitochondrial function and ATP production, helping cells reclaim vitality.
- Increased Physical Endurance – Boosts exercise tolerance in aged and chronically fatigued systems.
- Neuroprotection & Cognitive Resilience – Shields brain cells from oxidative stress and supports memory and learning.
- Cardiovascular Support – Promotes heart muscle health, reduces ROS, and helps treat cardiomyopathies.
- Kidney Function & Metabolic Health – Preserves mitochondrial structure in kidneys and organs; supports metabolic resilience.
Research Sources
- Improving mitochondrial function with SS‑31 reverses age-related redox stress and improves exercise tolerance
- SS‑31 treatment ameliorates cardiac mitochondrial morphology… in Taz⁻/⁻ (Barth) mice
- Elamipretide improves mitochondrial dysfunction, synaptic rescue in LPS-treated mouse hippocampus
- Kidney International article on SS‑31 improving glomerular aging and senescence
Technical Information
CAS Number: | 49557-75-7 |
PubChem CID: | 11764719 |
Formula: | C16H26CuN6O6 |
Synonyms: | Elamipretide, 736992-21-5, bendavia, MTP-131, Ocuvia |