CJC‑1295 (No DAC): Pulsatile GH‑Boosting GHRH Analog
Restore Natural GH Patterns, Enhance Recovery, Lean Mass, and Metabolism
CJC‑1295 (No DAC), also known as modified GRF (1‑29), is a designer analog of Growth Hormone Releasing Hormone (GHRH) that shows promising results in studies to stimulate the release of growth hormone from the pituitary gland. Unlike the extended-release DAC version, this peptide purportedly mimics the body’s natural, pulsatile GH rhythms, creating short but effective spikes in GH, ideal for those looking to perform research on optimizing growth hormone signaling without continuous elevation.
In studies, CJC‑1295 (No DAC) binds to the GHRH receptors in the anterior pituitary and:
- Triggers a short, natural GH pulse, similar to endogenous GHRH release.
- Minimizes cortisol, prolactin, and other stress hormone spikes, due to its targeted action and short duration.
- Stimulates IGF‑1 production in the liver, driving downstream anabolic and repair pathways.
- Encourages lipolysis and improved metabolic function through episodic GH signaling.
- Supports sleep quality and tissue repair through nightly GH release patterns.
This peptide potentially supports muscle growth, recovery, lean body composition, enhanced metabolism, and deep sleep, all while preserving receptor sensitivity and minimizing side effects. Because it’s short‑acting, during trials it’s typically dosed once or twice daily to coincide with exercise or circadian GH pulses.
Key Potential Benefits
- Physiologic GH Release – Mimics natural GH pulses (30–120 min effect), maintaining proper feedback loops and receptor sensitivity.
- Muscle & Tissue Repair – GH spikes promote IGF‑1 release, protein synthesis, tissue regeneration, and collagen production.
- Fat Metabolism – Elevates lipolysis and improves body composition when combined with exercise.
- Improved Sleep & Recovery – Supports deeper slow-wave sleep, essential for hormonal balance and tissue repair.
- Bone & Joint Health – Associated with growth and repair of bone and cartilage in animal models.
- Metabolic & Anti-Aging Support – Helps counteract age-related GH decline, improving metabolism, vitality, and wellbeing.
Research Sources
- Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC‑1295…
- Pulsatile secretion of growth hormone persists during continuous stimulation by CJC‑1295…
- Once‑daily administration of CJC‑1295 normalizes growth in the GHRH knockout mouse
- Sleep and endocrine changes after intranasal administration of growth hormone-releasing hormone in young and aged humans
Technical Information
CAS Number: | 863288-34-0 |
PubChem CID: | 91976842 |
Formula: | C152H252N44O42 |
Synonyms: | CJC1295 Without DAC, L-Lysinamide,L-tyrosyl-D-alanyl-L-a-aspartyl-L-alanyl-L-isoleucyl-L-phenylalanyl-L-threonyl-L-glutaminyl-L-seryl-L-tyrosyl-L-arginyl-L-lysyl-L-valyl-L-leucyl-L-alanyl-L-glutaminyl-L-seryl-L-alanyl-L-arginyl-L-lysyl-L-leucyl-L-leucyl-L-glutaminyl-L-a-aspartyl-L-isoleucyl-L-leucyl-L-seryl-L-arginyl-N6-[3-(2,5-dihydro-2,5-dioxo-1H- |