Ipamorelin: Natural Growth Hormone Catalyst
Enhance Recovery, Lean Mass, Sleep & Vitality
Ipamorelin is a highly selective growth hormone secretagogue designed to mimic the body’s natural ghrelin signal, stimulating the release of growth hormone (GH) from the pituitary gland. Unlike older GH-releasing peptides (like GHRP-6 or GHRP-2), Ipamorelin does so without raising cortisol, prolactin, or other stress-related hormones, making it potentially one of the cleanest and most targeted GH boosters available today.
Ipamorelin mimics the action of ghrelin by binding to the ghrelin/GHS-R1a receptor in the pituitary gland:
- Stimulates natural, pulsatile GH release, quickly raising GH levels without triggering cortisol, ACTH, or prolactin secretion.
- Supports downstream IGF-1 production, promoting muscle growth, tissue repair, and metabolic activity.
- Encourages lipid metabolism, mobilizing stored fat for energy.
- Facilitates recovery and deep sleep by enhancing GH-driven restorative cellular processes.
- Maintains hormonal balance, reducing stress-related side effects of broader GH releasers.
Its unique ability to potentially stimulate steady, natural pulses of growth hormone may allow it to support muscle building, fat loss, tissue repair, and sleep enhancement, without the side effects associated with synthetic GH administration. Ipamorelin shows potential in research to encourage downstream IGF-1 production, a key growth factor involved in cellular repair, metabolism, and recovery.
Key Potential Benefits
- Lean Muscle Growth – Promotes steady GH release that supports protein synthesis and lean muscle gains (average +16–27% weight gain in animal studies)
- Fat Loss & Metabolic Boost – Increased GH promotes lipolysis and improved body composition, especially when combined with exercise and protein intake.
- Improved Recovery & Tissue Repair – GH supports collagen production and tissue regeneration, aiding post-exercise and injury recovery.
- Better Sleep Quality – Many users report deeper slow-wave sleep and enhanced sleep patterns within weeks.
- No Cortisol or Prolactin Increase – Unlike other GHRPs, ipamorelin stimulates GH only, no cortisol or prolactin spikes.
- Fewer Hormonal Side Effects – Gentle, well-tolerated stimulation with minimal risk of endocrine imbalances.
Technical Information
CAS Number: | 170851-70-4 |
PubChem CID: | 9831659 |
Formula: | C38H49N9O5 |
Synonyms: | Ipamorelin, 170851-70-4, NNC-26-0161, Y9M3S784Z6, Aib-His-D-2-Nal-D-Phe-Lys-NH2 |