NMN (Nicotinamide Mononucleotide): NAD+ Precursor for Energy, Aging & Metabolism
Boost Cellular NAD⁺, Support Metabolic Resilience, and Promote Healthy Aging
NMN is a precursor to NAD+, a coenzyme essential for mitochondrial function, DNA repair, sirtuin activation, and cellular health. NAD+ levels naturally decline with age, leading to reduced energy, metabolic imbalance, and increased oxidative stress. By supplementing with NMN, research suggests it helps restore NAD+ levels, supporting cellular metabolism, stress response, and longevity.
Ongoing clinical trials and research studies indicate NMN functions by:
- Converted to NAD⁺ – NMN is rapidly absorbed and converted into NAD⁺ inside cells, fueling energy production and repair.
- Supports Mitochondrial Wellness – Boosted NAD⁺ enhances mitochondrial respiration and reduces age-related metabolic decline.
- Activates Sirtuins & DNA Repair – Facilitates repair enzymes (PARPs, sirtuins) for genomic stability and stress resilience.
- Improves Metabolism & Physical Function – Enhanced insulin response, walking performance, and muscle strength demonstrate metabolic and functional benefits.
- Supports Healthy Aging Biomarkers – Emerging clinical evidence indicates positive effects on telomere length and sensory health.
Clinical and preclinical studies also suggest NMN can enhance energy metabolism, improve insulin sensitivity, support cardiovascular and physical function, and even influence longevity markers like telomere length and hearing, making it a compelling option for anti-aging and wellness protocols.
While results are promising, most studies are short-term (<3 months) and involve smaller sample sizes. Larger, longer-term trials are needed to confirm long-term health benefits. NMN remains investigational in many countries and should be used under professional guidance.
Key Potential Benefits
- Raises NAD⁺ Levels – Oral NMN consistently increases NAD⁺ in blood cells by 11–38% over 60 days and shows similar boosts in other trials.
- Supports Physical Performance – Middle-aged adults improved six-minute walking test distance and grip strength in randomized trials.
- Enhances Insulin Sensitivity – Improves insulin response in prediabetic women and prevents insulin resistance compared to placebo.
- Promotes Healthy Aging Effects – Early data show improvements in telomere maintenance and hearing function in older adults.
- Safe & Well-Tolerated – Daily doses up to 300 mg over 3 months showed no serious adverse effects in middle-aged and elderly subjects.
Research Sources
Technical Information
CAS Number: | 1094-61-7 |
PubChem CID: | 14180 |
Formula: | C11H15N2O8P |
Synonyms: | 1094-61-7, nicotinamide mononucleotide, Nicotinamide ribotide, 2KG6QX4W0V, Pyridinium, 3-(aminocarbonyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)-, inner salt |